In today’s paper we discussed the connection between protein folding and function. For the alleles discussed describe how the sequence changes affects the protein folding, localization, and function.
The paper also descibes a number of techniques that were utilized to determine the protein structures. Give an example of one of these techniques and explain how the technique used added to our understanding of the enzymes described.
Finally, why is important that we know what alleles of the TMPT gene an individual harbors before therapy? What are the frequency of the A/B/C alleles?