One of the interesting processes that occur in science is the examination of what we don’t understand and are only beginning to appreciate. Todays paper is an example of that process. As we discussed in class the authors are examining the hypothesis that attempts to relate the actions of various therapeutic compounds with the regulation of the flow of information coming out of the nucleus of the cell.
This is not a new concept, but it is only now that we have laboratory tools that will allow us to examine not just the sequence of the genome, but the individual expression state of the genes within the genome.
The authors provide a nice introduction in the summary:
“The term ‘‘Epigenetics” refers to DNA and chromatin modifications that persist from one cell division to the next, despite a lack of change in the underlying DNA sequence. The ‘‘epigenome” refers to the overall epigenetic state of a cell, and serves as an interface between the environment and the genome. The epi- genome is dynamic and responsive to environmental signals not only during development, but also throughout life; and it is becoming increasingly apparent that chemicals can cause changes in gene expression that persist long after exposure has ceased.”
First I would like you to write a working definition of the terms
Then look through the paper and find an example of a phamacoepigenomic phenomenon. You will probably have to look up at least one reference about the phenomenon, but remember the paper has the references to the data within the text, use these references and PubMed to look up a paper or two.
Once you have gone through the paper and the references write a summary of the phamacoepigenomic phenomenon, explaining why the authors think this is an epigenetic form of regulation.