In our last class we reviewed three papers each covering as aspect of toxicogenomics. Taken together, the research suggested the power of combining numerous sources of data from toxicological studies including histology, chemistry, physiology, and ADME with genomic, transcriptomic, metabolomic and proteomic approaches.
Much like our systems toxicology discussion from the previous week, these quality of these approaches relied on establishing an understanding of the compounds that are being investigated and using known compounds as models for how genomic, transcriptomic, metabolomic and proteomic data should be used.
In writing questions for this set of papers I would ask that you focus on specifics from each paper, and design questions that combine concepts. Questions should not be a mater of looking something up, but rather of having to synthesize a solution to a problem.
1. List and Discuss Toxicogenomic goals. What is integration of data. describe with the help of an example (Waters MD and Fostel JM., 2004)
2. Describe in brief Toxicogenomic components. Write in detail about stages of comparative/predictive model. (Hamadeh HK. et al, 2002)